DMAP1 Antikörper (AA 31-130)

Produktnummer ABIN1714047

Dieser Anti-DMAP1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von DMAP1 in ELISA, ICC, IHC (p), IF (cc), IF (p) und IHC (fro). Geeignet für Xenopus laevis.

Kurzübersicht für DMAP1 Antikörper (AA 31-130) (ABIN1714047)

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Reaktivität: Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMAP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-DMAP1 Antikörper

Bindungsspezifität: AA 31-130

Kreuzreaktivität: Xenopus laevis

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DMAP1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu DMAP1

Target: DMAP1 (DNA Methyltransferase 1-Associated Protein 1 (DMAP1))

Andere Bezeichnung: DMAP1

Hintergrund:

Synonyms: DKFZp686L09142, DMAP 1, DNA methyltransferase 1-associated protein 1, DNMAP 1, DNMAP1, DNMT1-associated protein 1, DNMT1-associated protein 1, DNMTAP 1, DNMTAP1, EAF 2, EAF2, FLJ11543, KIAA1425, MAT 1-mediated transcriptional repressor, MGC55593, SWC 4, SWC4, zgc:55593.

Background: Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo.

Gen-ID: 55929